Research support

Soy protein consumption in the metabolic syndrome

grant holder
Prof. Dr. Paolo Magni
- Milano University, Italy

Evaluation of the health benefits of soy protein consumption in the metabolic syndrome: focus on visceral adipose accumulation and plasma subclasses.

Nutritional approaches for the primary prevention of cardiovascular diseases, currently the commonest cause of death worldwide, is, generally-speaking, a well-established strategy. Different food products, like plant-based foods and especially soy foods appear to be appropriate to contribute to this goal.

The aim of this 12-week intervention study was to assess the cardio-metabolic effects of a diet with
soy foods corresponding to 30g soy protein per day. Soy foods corresponding to 30g of soy protein per day were given to individuals with moderate metabolic syndrome (n=26) in substitution of animal foods containing the same protein amount. A parallel control group (n=27) followed a standard a lipid-lowering diet.

Soy intervention resulted in a reduction in several metabolic syndrome features. Moreover, in the soy group we observed a significant improvement of median percentage changes for body weight (-1.5 %) and body mass index (-1.5 %), and for atherogenic lipid markers, like total cholesterol (-4.85 %), LDL-cholesterol (-5.25 %), non-HDL-cholesterol (-7.14 %) and apolipoproteinB (-14.8 %).

In conclusion, 30g soy protein per day in a lipid lowering diet significantly improved a relevant set
of biomarkers associated with cardiovascular and metabolic risk.

Dr Magni explains the results in this video recorded at the 2016 VegMed conference.

Paolo Magni


Ruscica M, Pavanello C, Gandini S, Gomaraschi M, Vitali C, Macchi C, Morlotti B, Aiello G, Bosisio R, Calabresi L, Arnoldi A, Sirtori CR and Magni P. Effect of soy on metabolic syndrome and cardiovascular risk factors: a randomized controlled trial. Eur J Nutr 2016.